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IL-18 can activate intestinal epithelial cells to produce antimicrobial peptides (AMPs) and stimulate the production of Th1, NK and NKT to secrete IFN-, or combine with IL-12 to induce more IL-17-secreting T cells [102, 103]

If headaches persist beyond 3 to 4 days, consider reducing the dose

Allergy control, through avoidance, medication, or immunotherapy, can prevent recurrent symptoms

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