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The increasing global cancer burden, with an estimated 20 million new cases and 9.7 million deaths globally in 2022 with projections indicating a 77% increase in incidence by 2050 and the limitations of current treatments, which are exemplified by the fact that despite advancements in cancer detection, treatment and supportive care, survival outcomes remain suboptimal for many patients, together highlight an unmet need for novel therapeutic agents that are both effective and safe (1)
Peptides tend to act more locally or on specific cell types
Neurite outgrowth promotion: In developmental and regeneration contexts, Thymosin Beta-4 promotes axon and dendrite growth
Effects of phenobarbital treatment on serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs
To determine whether GSH depletion can also exert protective effects in a primarily MASH model, we overexpressed Chac1 in mouse liver using AAV8 followed by challenging mice with methionine/choline-deficient diets (MCDs) to induce MASH
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