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Liver glutathione declines 35-50% in aged animals [7] , while brain glutathione drops by at least 50% over adult aging [8]

For vulnerable patient populations, for example, pediatric patients needing long-term medical treatment, drug tolerability and safety should be considered in addition to effectively controlling disease activity

This is often driven by the visceral fat component rather than caloric excess

AOD-9604 targets fat cells and promotes their breakdown without affecting blood sugar

Using two incretin-based compounds simultaneously would create overlapping receptor activation at the GLP-1 and GIP sites, dramatically increasing side effect risk without proportional efficacy gains