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Weight loss should be gradual, aiming for 0.5-1 kg per week, achieved through a combination of reduced calorie intake and increased physical activity

Further, lipid peroxidation has been found to decrease the membrane's ability to uptake glucose as well as respond to varying levels of immune challenges[7]

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These findings underscore four core principles of chronotherapeutic MRIS management: Dawn BMAL1 activation upregulates hepatic CPT1A, driving peak FAO at sunrise, a rhythm exploited by administering CPT1A inhibitors at dawn to maximally suppress pathological lipid flux