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Many mutational factors that cause PD, including -syn, Leucine-rich repeat kinase 2 (LRRK2), Glucocerebrosidase (GBA), Parkin RBR E3 Ubiquitin Protein Ligase (PRKN), Parkin RBR E3 Ubiquitin Protein Ligase (PINK1), and Parkin RBR E3 Ubiquitin Protein Ligase (DJ-1), etc

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Therefore, GSH itself may not be effective at direct reduction of reactive oxygen species under physiological conditions

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