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The combination of DNase-I + amikacin resulted in a strong increase in dead biofilm compared to DNase I treatment alone, and the triple therapy combination of GSH + DNase-I + amikacin showed the highest level of biofilm disruption (Figure 3C)

GSH/GSSG is a reliable indicator of cellular redox status, and a chronic reduction in GSH/GSSG reflects a reduced antioxidant capacity and increased vulnerability to oxidative damage

His 18 plays a critical role in catalysis by removing resonance stabilization in the carboxylate group and activating the oxyanion for attack

Unlike regular glutathione, which is often broken down in the digestive system, liposomal glutathione is encapsulated in liposomestiny fat molecules that improve its absorption

FIGURE 1 3.2 FOXO4-DRI effectively improves vascular function in prematurely aging mice To further explore the role of FOXO4-DRI in aged mice, we constructed prematurely aging mouse model by administering D-galactose (200 mg/kg) intraperitoneally for 8 weeks