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COX-derived reactive species and transcriptional activity of interleukin-1beta ( IL-1 ), interleukin-6 ( IL-6 ), tumor necrosis factor- ( TNF- ), cyclooxygenase-2 ( COX-2 ), and inducible nitric oxide synthase ( iNOS ) are increased during aging (Michaud et al., 2013

Histological analyses described increased fibroblast density, improved collagen alignment and local neovascularization

Variables analyzed include demographics, symptom onset, clinical features, imaging, genetics, and vascular risks

10.1038/sj.jidsymp.5650007 21 KhatifH.BazziH

Anti-aging effects : HGH helps improve skin elasticity, energy levels, and overall vitality