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Furthermore, we elucidate a possible mechanism through which naltrexone may attenuate the antidepressant effects of ketamine by demonstrating opioid modulation of ketamine-induced glutamatergic activity

Unlike systemic immunosuppressants, KPV appears to act locally at mucosal surfaces without broad immune dampening

In addition, IF stimulates gut microbial resilience, enabling a faster and more robust recovery of the microbiota following dietary or environmental perturbations, thereby reducing the risk of dysbiosisa condition strongly linked to inflammatory and metabolic disorders [84]

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