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And so, if you go back to, Why does normal metabolism generate these oxidants? Well one of the things that happens is because a certain percentage of the fuel you have burned in your mitochondria are generating these oxidants, they will have feedback loops where if you start generating too many oxidants then they will regulate pathways that stop energy from coming into the mitochondria because, as a feedback loop to prevent damage because theyre exposing an inefficiency in your ability to burn that energy and they are shutting down the energy burning to prevent further damage