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Daily administration of Rehmannioside D (76 mg/kg for 2 weeks) can improve the estrous cycle in DOR rats, increase ovarian index, enhance the number of primordial and mature follicles, reduce the number of atretic follicles, decrease apoptosis in ovarian granulosa cells, inhibit FSH and LH levels, and upregulate E2 expression

and 3) clearing the lysate prior to purification is not required

Head Neck 37:727734 Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K (2019) Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes