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An intradermal test dose is recommended before cyanocobalamin injection is administered to patients suspected of being sensitive to this drug

It can also make it easier to see if you have missed a dose or are running out

In rare cases you may suffer bruising, redness, swelling or itching at the injection site which is normally transient and limited to 48 hours

Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)

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