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By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

In the new study, the MIT and Dana-Farber team wanted to extend that search into tissue samples from patients with pancreatic cancer, using immunopeptidomics a strategy that involves extracting the peptides presented on a cell surface and then identifying the peptides using mass spectrometry

They serve various functional roles, especially in muscle tissue regeneration

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Because of the damage doxorubicin does, it creates large numbers of senescent cells