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TAO is characterized by an increase in orbital contents that can cause the orbit to expand to even eight times the normal size, with a risk of secondary intraocular pressure increase, optic nerve compression, subsequent myofiber degeneration leading to fibrosis, and restraint effects on the affected muscle leading to restrictive myopathy and diplopia (335)

This is particularly important for individuals exposed to environmental toxins or those with liver conditions

Not perfect, but far less waste than 4mg unused