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[DOI] [PubMed] [Google Scholar] 71.Higgins J.P., Altman D.G., Gtzsche P.C., Jni P., Moher D., Oxman A.D., Savovi J., Schulz K.F., Weeks L., Sterne J.A

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employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development

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PMCID: PMC2701135