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Inhaled GSH delivers directly to the lungs and is often considered the preferred route for pulmonary effects

It is more common in older adults

Its decreasing levels can contribute to such chronic diseases as cardiovascular issues, diabetes, and cancer The production of glutathione can decline with age or in response to excessive stress and toxin exposure

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748 Additionally, altered vascular shear stress contributes to LSEC senescence, disrupting sinusoidal remodeling and delaying liver regeneration