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However, increasing evidence indicates that distinct anatomical sites are functionally interconnected through systemic axessuch as the gutmammary and gutlung axesmediated by microbial metabolites and immune signaling via circulation 7,8

In addition, iodine supplementation in iodine-deficient areas has been associated with an increased risk of thyrotoxicosis, supporting the U-shaped relationship between iodine status and thyroid disorders [17, 18]

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