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Initial response at 4 to 8 weeks

In diurnal animals like the Nile grass rat, dim LAN paradoxically enhanced immune markers including plasma IgG and DTH, whereas in nocturnal rodents, such as Siberian hamsters and C57BL/6 mice, dim light exposure and phase shifts typically led to immune suppression, delayed wound healing, reduced febrile responses to lipopolysaccharide (LPS), and diminished bactericidal activity 93,94,95,96