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A review of 100 cases

Tirzepatide may cause gallbladder problems, including gallstones

doi: 10.1038/s41586-019-1847-2 139 GalKIbrahimMXWielCSayinVIAkulaMKKarlssonCet al

In the low-overdose patient (A), increasing zonation (20%80%) increased pericentral necrosis (by 13.2 times), with the number of necrosed cells increasing from 22 (1.29%) at 0% to 66 (3.87%) at 80% zonation, whereas in patient D (high overdose), increasing CYP450 zonation (20%80%) increased pericentral necrosis (by 3.33 times) from 36.25% (618 necrosed cells) to over 48% (831 necrosed cells), leaving only over 37% of healthy cells

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