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Hepatotoxicity caused by APAP overdose is one of the leading causes of acute liver failure (ALF) in the US and in some parts of Europe, limiting its clinical application

Examples exist of brothers, harboring the same mutation, with one afflicted by the aggressive childhood form while the other suffering from a slowly progressive adrenomyeloneuropathy (Palakuzhiyil et al., 2020)

10.1186/s13073-023-01179-2 72 KarakoseE.WangX.WangP.CarcamoS.DemirciogluD.LambertiniL.et al (2024)

It is characterized by a broad spectrum of activity including anti-inflammatory, antipyretic, analgesic, cardiovascular, hypoglycemic, diuretic, immunomodulatory, dermatological, anti-bacterial, anti-fungal, anti-ulcer, anti-tumor, and anti-malarial effects

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