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Experimental design Figure 1 shows the experimental design

This suggests that newborns have a high requirement for this specific antioxidant to help them transition to life outside the womb and protect their delicate tissues from oxidative damage

Um estudo de Sikiric et al

Reports that newborns with a complete lack of insulin effects due to inactivating defects in the INSR gene can now survive for extended time into adolescence when treated with recombinant IGF-I, that stimulate glucose uptake via the IGF1R sharing common signaling pathways with the INSR, support an important direct role of IGF-1 signaling on metabolism (93)