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Figure 2 3.2 TNF triggers the release of mtDNA and the activation of cGAS-STING signaling in RA TNF, a multifunctional cytokine for homeostasis and disease pathogenesis, is highly expressed in rheumatoid joint tissues ( Growing evidence has indicated that obesity plays a pivotal role in multiple aspects of RA ( 3.3 cGAS-STING signaling participates in the abnormal activation of FLSs FLSs exhibit abnormal activation and proliferation in the synovium of RA patients, serving as primary effector cells responsible for mediating joint destruction and synovitis ( In vitro , transfection of dsDNA upregulated the expression of IFN- and IFN- in RA-FLSs, suggesting that cytosolic dsDNA accumulation enhanced the IFN-I signature

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