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Clinically, STAT5 levels correlate with lactate concentration and PD-L1 expression in bone marrow samples, and genetic disruption of PD-L1 or PD-1 blockade can restore CD8 T-cell function, supporting this STAT5E3BPlactylation axis as a potential biomarker and therapeutic target for improving responses to immune checkpoint inhibition in AML [167]

Meanwhile, we also note that although existing studies have established significant associations between intestinal fungi and CLDs, the generalizability of their conclusions is limited by relatively small sample sizes (as shown in Tables 15)