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They approach what bariatric surgery produces, which is roughly 25 to 30% weight reduction, and they do so with a weekly subcutaneous injection rather than a surgical procedure

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210 However, studies of 5-HTP are few and were mostly conducted over 30 years ago with little interest in 5-HTP for migraine since this time, which coincides with the approval of the first selective serotonin reuptake inhibitor (SSRI) drugs

Exceeding this window risks reduced potency, though the medication typically doesn't become harmful