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10.1016/s0024-3205(99)00410-5 61 FriedmannT.RoblinR

But the solution only lasts 4 to 8 weeks

The combination of the vascular components [i.e., endothelium, pericytes and smooth muscle cells (SMCs)], glial cells (i.e., astrocytes and microglia) and neuronal cells creates an interacting compartment called neurovascular unit (NVU), which is essential for regulating the BBB permeability, neurovascular coupling, cell-matrix interactions and in turn for contributing to the whole tissue homeostasis, including angiogenesis and neurogenesis (Sweeney et al., 2019)

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It warrants further investigation