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Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

Anti-inflammatory foods may complement the anti-inflammatory effects of the peptides

A recent sophisticated review reported relapse rates in a general range between 40% and 50% over a 2-year period following the discontinuation of the anti-TNF treatment

Tissues were fixed with buffered formalin, and paraffin sections were made for histopathological analysis including TUNEL assay

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