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First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]

doi: 10.1172/jci62636 262

18 Hypercalcemia Acute pancreatitis due to hypercalcemia is uncommon, but it can be life-threatening