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Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use

You can apply an ice pack to the muscle area about some time after the injection

Nanomedicine 11, 313 (2015).CrossRefGoogle ScholarPubMed Tiwari, P.M., Vig, K., Dennis, V.A., and Singh, S.R.: Functionalized gold nanoparticles and their biomedical applications