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When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

Sulfur rich foods (garlic, onions, cruciferous vegetables), high quality protein (eggs, grass fed meat, whey), selenium sources (Brazil nuts, sardines), and colorful produce rich in vitamin C all support natural glutathione synthesis

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Genet 24 , 109132 (2023)

Noctor G, Foyer CH (1998) Ascorbate and glutathione: keeping active oxygen under control