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Many studies to date have had a small sample size, meaning that very few people took part in the research

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274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)

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The following table gives an overview of all of those currently under investigation: Vitamin B12 One Vitamin, Many Effects Not all forms of vitamin B12 are the same