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METHYLENE BLUE SENSITIVITY 1 (MBS1) is required for acclimation of Arabidopsis to singlet oxygen and acts downstream of -cyclocitral

This relative deficiency contributes to mitochondrial dysfunction, impaired substrate metabolism, and metabolic inflexibilitythe inability to efficiently switch between carbohydrate and fat oxidation based on substrate availability

Furthermore, the loop harbors multiple glycine residues (G194, G196, G198, G202, and G206), with all but G202 in the glutathione mimic far from the active site Fe(II) (Fig

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