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6 They are part of the innate immune defense system of organisms with multiple biological activities such as antibacterial activity, antifungal activity, anticancer activity, and immune system regulation

However, absence of evidence is not evidence of absence. The sample sizes were small, and rare side effects (or ones that occur with prolonged use) could easily have been missed

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Recently, investigations indicated that protegrin-derived SynB1 CPPs, and Antennapedia homeodomain-derived penetratin (antp), could increase the doxorubicin delivery (an anticancer drug) across the BBB, which indicates their ability to treat glioblastoma [110, 111]