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Description

Evening: Nighttime is when the skin's barrier repair and collagen-related activity are often most active, so an evening application can coincide with those processes

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Expansion of adipose tissue increases expression of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1), which converts inactive cortisone to active cortisol, thereby amplifying cortisol exposure in local tissues [82, 83]

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