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Uremic toxins and pathogen-associated molecular patterns activate the immune system and sustain systemic inflammation ( Figure 4 ) [34]

Damaged mitochondria leads to more output of free radicals

The nitric oxide system plays an essential role in sphincter regulation

doi:10.1097/00000658-200209000-00013 11 Gumina S, Passaretti D, Gurz MD, Candela V

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