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Furthermore, various mitochondrial genes and metabolism both play an important role in this process (Dixon et al., 2019)

GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]

To create glutathione, NAC bonds with two other amino acids: glutamine and glycine

Int J Mol Sci 24(6):5600 Zhou B, Lin W, Long Y, Yang Y, Zhang H, Wu K et al (2022) Notch signaling pathway: architecture, disease, and therapeutics

The most common cause of dementia is Alzheimer's disease, and the average life expectancy for someone with Alzheimer's is about 8 years