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As a result of pro-oxidative conditions, a variety of transcription factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), AP-1, p53, hypoxia-inducible factor-1 (HIF-1), peroxisome proliferator-activated receptor gamma (PPAR), -catenin/Wnt, and Nrf2, are activated 83,84,85,86 (Fig

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