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The BH 4 /CoQ 10 system is comprised of two components, namely the ferroptosis suppressor protein 1 (FSP1)/CoQ 10 axis and the guanosine triphosphate cyclohydrolase 1 (GCH1)/BH 4 axis, and both pathways have been shown to inhibit ferroptosis independent of the xCT/GPX4 system [37]

A post hoc power analysis was conducted with G*Power 3.1.9.2 45 ( The power (1- error probability) was calculated by statistical test ANOVA: Repeated measures, within factors at the significance level ( error probability, p = 0.05)