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10.1172/JCI106460 J

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It's an involved process, Khatri says, But because of the multiple visits, you're monitored way more than you would be as a layperson just, you know, walking around in the world. Con: You could experience unpleasant side effects or an adverse reaction No matter how closely you are monitored, the drug or therapy being tested could cause an unpleasant side effect, ranging from minor (such as a sore arm at the injection site) to more severe, called an adverse reaction

The logic is that GH-axis compounds are not dose-linear in a helpful way past a point: once the pulse is being driven hard, adding drug mostly buys more IGF-1 exposure, more fluid retention and more glucose disturbance rather than proportionally more benefit

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