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In some embodiments, the otoprotectant is a compound of Formula (XI): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

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Sterile, 0.9% benzyl alcohol preserved water for laboratory peptide reconstitution