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However, it is known that through dietary intake and/or supplementation, antioxidants such as vitamin C, E, and carotenoids are deposited into the epidermis at higher concentrations compared with the dermis [4,5,6], which suggests the importance of inside to outside treatment of the skin

These effects result from enhanced expression and membrane trafficking of GLUT1, mediated via TXNIP downregulation due to mitochondrial complex I inhibition

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At picomolar to nanomolar concentrations, GHK-Cu stimulated the synthesis of collagen in skin fibroblasts, increased accumulation of total proteins, glycosaminoglycans (in a biphasic curve) and DNA in the dermal wounds in rats

Nutrients (2013) 5(3):70010