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Each component is associated in published preclinical literature with distinct mechanistic pathways, and the blend format allows laboratories to prepare all four under matched conditions for parallel single-agent and combined-arm experiments

de la Rosa Rodriguez, M

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Although the serum glycerol levels were similarly increased in WT/HFD mice and Insr P1195L/ +/HFD mice, the blood glucose levels after CL316432 administration were significantly higher in Insr P1195L/ +/HFD mice, indicating that enhanced lipolysis exacerbates hyperglycemia in Insr P1195L/ +/HFD mice

human efficacy is unproven [3] [4]