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One participant experienced a single adverse reaction to the study medication, cephalgic paresthesia, which resolved within 1 h

This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

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56 Urine Albumin-to-Creatinine Ratio The urine albumin-to-creatinine ratio (UACR) is another test used to assess kidney function