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According to the Mayo Clinic, IGF-1 is produced primarily by the liver in response to growth hormone stimulation, and levels remain relatively stable throughout the day

Storck SE, Kurtyka M, Pietrzik CU

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Month 15, 18, 21 (Option Period): Quarterly technical progress reports detailing technical progress made, tasks accomplished, major risks/mitigations, a technical plan for the remainder of Phase II Option Period (with necessary updates as in the parenthetical remark for Months 9 and 12), planned activities, trip summaries, and any potential issues or problem areas that require the attention of the DARPA PM

Under glucose-deprived conditions, the knockout of IDH1 or ME1 significantly reduces the NADPH/NADP+ and GSH/oxidized GSH ratios, leading to elevated ROS levels and increased cell death in cancer cells (94)