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Preclinical studies demonstrated that AOD-9604 was generally safe after chronic oral application in rats and cynomolgus monkeys, with no genotoxic concerns identified

10.3390/nu13072381 59 ShenH.RodriguezA

The findings suggest that activating SIRT1 could serve as an effective strategy to disrupt the pathological cycle of MASLD, offering advantages in system-wide regulation and synergistic intervention

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Routine follow-up EEG monitoring during the GF-MKD intervention was not performed, as the study was designed to assess metabolic and behavioral outcomes rather than electrophysiological changes