+ Are there any side effects of B12
The NHS Inform Scotland guidance and the Vegan Societys recommendation align: a 10-microgram daily B12 supplement, or a 2,000-microgram weekly supplement, is enough for the vast majority of plant-based eaters
From published studies, while the causal direction is clear between BMI and glucose, this is not clear between BMI and B 12 and folate
Mechanism of Action and Target Biology NNMT Enzyme and Function: Nicotinamide N-methyltransferase (NNMT) catalyzes the SAM-dependent methylation of nicotinamide: Reaction: Nicotinamide + SAM 1-methylnicotinamide (1-MNA) + S-adenosylhomocysteine (SAH) Expression: Liver, adipose tissue (particularly visceral), smooth muscle, some neurons Regulation: Increased expression in obesity, diabetes, aging, certain cancers Substrates consumed: Nicotinamide (NAD+ precursor) and SAM (methyl donor) 5-Amino-1MQ Inhibition Mechanism: Competitive inhibitor with respect to nicotinamide substrate IC: Submicromolar range for NNMT enzyme Selectivity: Minimal inhibition of other methyltransferases at relevant concentrations Result: Increased intracellular nicotinamide availability for NAD+ salvage pathway Downstream Effects of NNMT Inhibition: 1
Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women
