Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters
Serum Protein Profile Effects Sackmann-Sala et al., Growth Hormone & IGF Research (2009) Sackmann-Sala and colleagues used quantitative proteomic analysis to characterize the downstream effects of CJC-1295 administration on the serum protein profile in healthy adult subjects
In patients with a rotator cuff tear a Kenalog injection would be my treatment of choice for those patients who are elderly and most likely not going to be proceeding with a rotator cuff repair
Kantarjian H, O'Brien S, Ravandi F, Borthakur G , Faderl S, Bueso-Ramos C, Abruzzo L, Pierce S, Shan J, Issa JP, Garcia-Manero G
This pathway operates independently of metabolic regulation but is particularly responsive to fluctuations in intracellular Ca 2+ levels and signaling