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The mitochondrial apoptotic route responds to an array of stress signals, such as mitochondrial damage, ER stress, and oxidative stress

Curcumin Curcumin, a polyphenolic compound initially identified as diferuloylmethane in turmeric rhizomes, has demonstrated protective effects against oxidative damage resulting from iron accumulation in cells (124)

It is released quickly and in large quantities into the bloodstream during hepatocellular injury and the elevations in its activity are more rapid than AST or ALT

In vitro, in the absence of Zn, VDR conformation cannot occur, and vitamin D function fails (240, 241)

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