Using the FDA's body-surface-area conversion, a 10 mcg/kg rat dose maps to roughly 1.6 mcg/kg in a human, but most practitioners use higher doses based on clinical experience
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While it might seem like simple math a 1000 micrograms (mcg) B12 shot is equal to a 1,000 mcg B12 supplement its not that simple
However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance
Every entry uses the 10 mg/mL concentration because it offers the cleanest math across all vial sizes and maintains consistency whether you switch between a 10 mg and 30 mg vial next month