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Fatigue, slow wound healing, and prolonged nausea are frequently nutritional problems, not inevitable parts of surgery

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Depletion of PAPS due to lack of inorganic sulfate or due to genetic defects of enzymes participating in PAPS synthesis may lead to reducing of sulfonation capacity which could affect the metabolism of xenobiotics or disrupt the equilibrium between synthesis and degradation of active endogenous compounds

Even if virtually, all cell types synthesize GSH, the main source of the tripeptide is liver where the bulk of cysteine, the rate limiting amino acid, derived from diet is metabolized