Unlike fat-soluble vitamins (A, D, E, K), B12 doesnt accumulate to toxic levels from dietary or supplement intake in most circumstances
The precision of the method is defined as the closeness of agreement between a series of measurements obtained from multiple sampling of the same homogeneous sample under the prescribed conditions [50]ICH Q2 (R1), Validation of analytical procedures: text and methodology, in Proceedings of the International Conference on Harmonization, Geneva, Switzerland, 2005
Theres an important physiological distinction worth understanding here: blood serum levels of a nutrient can appear adequate on a standard blood test while cellular levels the amounts actually available inside the tissues where healing occurs remain insufficient
Second, we did not analyze the effect of individual medications, except the use of NSAIDs, on the renal prognosis among the patients with RA
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