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It's important to investigate the cause of deficiency with tests such as anti-intrinsic factor antibodies and to check folate status

Weeks 1 to 4: Starting Dose Titration Starting dose is 0.25 milligrams of semaglutide weekly, plus 1,000 micrograms of B12

- [Retatrutide Phase 2 Trial Supplementary Appendix: Drug Preparation]( *New England Journal of Medicine*, 2023

Pharmacy: Each batch of medication undergoes extensive quality checks by licensed, certified pharmacists to help ensure safety and potency

The overall quality of evidence for this outcome was low due to serious imprecision (low number of trials and participants)